The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different (...) research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge. (shrink)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

In its opening chapters, ‘Languages of the Unheard’ offers a broad account of militancy as an aid to democracy and a principled response to the intransigence of elites and the unresponsiveness of institutions to the public interest. It proposes an understanding of militancy as a civic virtue and a contribution to democratic politics, relying on a normative conception of ‘autonomous democracy.’ In the second part of the book, this understanding of admirable militancy is applied to a wide range of protest (...) styles, including the nonviolent civil disobedience promoted by Gandhi and King, the disruptive direct action of strikes and other forms organized disruption, the rioting and black blocs of militant street protest, and the armed insurgency promoted by both urban and rural guerrilla groups. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:F. R. Leavis (Modern Cultural Theorists)Stephen OgdenF. R. Leavis (Modern Cultural Theorists), by Anne Samson; x & 196 pp. Toronto: University of Toronto Press, 1992, $45.00 cloth, $16.95 paper.If it is an overstatement to say that the waves of change currently disturbing the teaching of English in universities originated from the splash made by F. R. Leavis at Cambridge beginning in 1933, Anne Samson’s account of the (...) theorist’s influence scarcely admits it. Her chapter titles—“Leavis and the Growth of English Studies,” “English as a University Subject,” “Literary ‘Theory’ and Constituting the Canon”—indicate not only the range of issues connected with F. R. Leavis’s name but also his significant involvement in their genesis.Samson’s book portrays Leavis as the efficient cause in the establishment of university English as a critical, or more accurately a diagnostic, enterprise. At an early professional cost (he was denied faculty appointment at Cambridge for five years), Leavis helped cut English curricula free from philology, languages, and classical studies; a responsibility Samson partially excuses by connecting Leavis’s motivating principles back through Matthew Arnold to Dickens and Carlyle and even to one “Reverend H. J. Rose, a leading figure in the founding of King’s College, London... declaring in a sermon delivered in 1826 that literature teaches ‘the wisdom of men better and wiser than ourselves’ and prepares for the ‘examination of those moral and intellectual truths which are not only the worthiest exercise of our reason, but most concern our future destiny’” (p. 12).This moralism Samson sees as the central and redeeming principle in Leavis’s system. Specifically, she identifies the Condition of England debate—over the state of culture and economics in a “‘technologico-Benthamite world’” (p. 63)—as the key to Leavis’s literary criticism, his influential journal Scrutiny, and his wide-ranging reform endeavors. “Literature mattered to Leavis because he believed it to be the means, above all others, of combating the ills of a mechanised, constantly changing world and of restoring the heritage of those dispossessed by the machine” (p. 3).Professionally asserting the primacy of criticism over scholarship, then in his writings making no distinction between the literary and the social, Leavis ultimately refused any separation between literature and life. Samson carefully [End Page 360] traces this development in Leavis’s general theory in order to bring out its easily-overlooked implication for the social position of a literary academic. She quotes this crucial passage from Leavis: “The critic... is as much concerned with the health of the mind as any doctor with the health of the body. To set up as a critic is to set up as a judge of values... For the arts are inevitably and quite apart from any intentions of the artist an appraisal of existence” (pp. 15–16). No longer a mere scholar, or the type of irrelevant empiric Leavis so hated in the person of C. P. Snow, the Leavisite theorist is the grand physician diagnosing all society’s ills. Literary artists and their writings, so far from forming the most important part of literature, become perfectly irrelevant—“quite apart”—with the medicocritic prescribing universally “of existence.”Samson’s treatment of Leavis is analytical, though enjoyably and consistently biographical. For instance, her final, and largest, chapter shows the moralist model of the literary critic (the “judge of values”) in action by detailing the history of Leavis’s complete reversal of estimation between T. S. Eliot and D. H. Lawrence. Leavis originally gave Eliot “hero-worship” (p. 162) and dismissed Lawrence as “mechanical” (p. 157). But concurrent with Eliot’s progress to Anglo-Catholicism, Leavis’s moral judgments overturned and, true to type, he increasingly censured Eliot’s writings by diagnosing problems in the man, while he grew to idolize Lawrence; ironically for “rescuing life from... inner mechanisation” (p. 169).Such inconstancy, here expressed in every word, Samson sees as an historical mark of character which places Leavis among the “Great Men of Ideas” (p. 172).Stephen OgdenSimon Fraser UniversityCopyright © 1995 The Johns Hopkins University Press... (shrink)

An exploratory pilot study with a small homogenous sample of Christian English speaking participants provided support for an alternative research hypothesis that a Christ consciousness contemplation with Heart Prayer of HeartMath techniques was significantly associated with increasing psychophysiological coherence, sense of coherence, spirituality and health perceptions. Participants described feelings of a peaceful place in oneness and connection with Christ. Integrative findings point towards Christ consciousness as an ultimately non-dual process of sensing vibrational resonance radiating from the human heart. Implications for (...) further research are discussed. (shrink)

This integral investigation explored phenomenological and neurophysiologic, individual and collective dimensions of Christian Trinitarian meditation experiences in a volunteer, convenience sample of 10 practicing Christians, 6 men and 4 women, with a mean age of 48 years and an age range from 21 to 85 years. Participants meditated for a minimum period of 15 minutes, during which neurophysiologic data in the form of electroencephalographic (EEG), electromyographic (EMG), blood volume pulse (BVP) and respiratory activity were recorded. A phenomenological analysis indicated that (...) the meditation process generally involved a movement from body to mind to spirit as evident in reports of an increasingly relaxed, contented and focused state of consciousness characterised by Christian Trinitarian imagery, wonder, surrender, peace, bliss, openness and formlessness. The neuropsychological findings indicated significant increases, from baseline to meditation recordings, in the alpha and beta range, accompanied by increasing mean trends in the theta and gamma range, and decreasing mean trends in the delta range, EMG, BVP and respiration. Integrative findings indicated the practical theological value of small doses of Christian Trinity meditation to enhance spiritual life for those forms of waking, thinking, conscious behaviour needed in everyday world involvement and healing. Findings were discussed in relation to further integrative investigations and interventions with practical theological implications. (shrink)

The research was generally motivated by a dearth of studies on joy, and particularly inspired by a book of joy celebrating the inter-spiritual dialogue between the Dalai Lama and Desmond Tutu. Its aim was to investigate whether the direct contemplation of joy would be associated with improvements in psychophysiological coherence, spirituality and various positive emotions and feelings. Integrative quantitative and qualitative findings emerging from a small pilot study, including a convenience sample of six participants with a mean age of 42 (...) years and age range of 25-69 years, supported the research hypothesis. Significant quantitative increases in psychophysiological coherence, spirituality and positive feelings were coherently and consistently supported by participants' individual and collective experiences. Integrative discussion amplified the paradoxical theme of joy through suffering in human emotional and spiritual life. (shrink)

The Meaning of Life and the Great Philosophers reveals how great philosophers of the past sought to answer the question of the meaning of life. This edited collection includes thirty-five chapters which each focus on a major figure, from Confucius to Rorty, and that imaginatively engage with the topic from their perspective. This volume also contains a Postscript on the historical origins and original significance of the phrase 'the meaning of life'.

There was a man of the Pharisees, named Nicodemus, a ruler of the Jews: the same came to Jesus by night…John 3: 1–2A lady asked the famous Lord Shaftesbury what religion he was of. He answered the religion of wise men. She asked, what was that? He answered, wise men never tell.Diary of Viscount Percival , i, 113NEWTON AS HERETICIsaac Newton was a heretic. But like Nicodemus, the secret disciple of Jesus, he never made a public declaration of his private (...) faith – which the orthodox would have deemed extremely radical. He hid his faith so well that scholars are still unravelling his personal beliefs. His one-time follower William Whiston attributed his policy of silence to simple, human fear and there must be some truth in this. Every day as a public figure and as the figurehead of British natural philosophy, Newton must have felt the tension of outwardly conforming to the Anglican Church, while inwardly denying much of its faith and practice. He was restricted by heresy laws, religious tests and the formidable opposition of public opinion. Heretics were seen as religiously subversive, socially dangerous and even morally debased. Moreover, the positions he enjoyed were dependent on public manifestations of religious and social orderliness. Sir Isaac had a lot to lose. Yet he knew the scriptural injunctions against hiding one's light under a bushel. Newton the believer was thus faced with the need to develop a modus vivendi whereby he could work within legal and social structures, while fulfilling the command to shine in a dark world. This paper recovers and assesses his strategies for reconciling these conflicting dynamics and, in so doing, will shed light on both the nature of Newton's faith and his agenda for natural philosophy. (shrink)

This paper discusses the announcement by a team of researchers that they identified a genetic influence for a range of “antisocial” behaviours in the New Zealand Māori population (dubbed the “warrior gene”). The behaviours included criminality, violence, gambling and alcoholism. The reported link between genetics and behaviour met with much controversy. The scientists were described as hiding behind a veneer of supposedly “objective” western science, using it to perpetuate “racist and oppressive discourses”. In this paper we examine what went wrong (...) in the dissemination of the research. We chose as our framework the debate around the “internal/external” responsibilities of scientists. Using this discourse we argue that when the researchers ventured to explain their research in terms of social phenomena, they assumed a duty to ensure that their findings were placed “in context”. By “in context”, we argue that evidence of any genetic influence on behavioural characteristics should not be reported in isolation, but instead presented alongside other environmental, cultural and socio-economic influences that may also contribute to the studied behaviour. Rather than imposing a new obligation on scientists, we find this duty to contextualise results is in keeping with the spirit of codes of ethics already in place. Lessons from the “warrior gene” controversy may assist researchers elsewhere to identify potential areas of conflict before they jeopardise research relationships, or disseminate findings in a manner that fuels misleading and/or potentially discriminatory attitudes in society. (shrink)

This volume is the first full-length attempt from within the fields of theological and biblical studies to grapple with "the turn to the animal" currently underway in the humanities, a turn catalyzed in part by the animality theory that has issued from such thinkers as Jacques Derrida and Donna Haraway.

Kirshner may be right that domestic politics does matter, but he does not tell us how to understand domestic politics. How are we, for instance, to understand domestic cohesion? How are we to understand national purpose? More important, what is the impact of nuclear weapons? Do these weapons obliterate all past information about power? Are nuclear weapons all that matter? Is it possible to fight a limited nuclear war? Is North Korea as strong as the United States? Such questions have (...) been around since the 1950s. Kirshner does not help us to answer them. (shrink)

L'importance de Duns Scot (1265?-1308) pour l'histoire de la métaphysique et de l'éthique n'est plus à démontrer. En demandant à Olivier Boulnois de recueillir ces études, Philosophie tente de se faire l'écho de la floraison récente de travaux consacrés à cet auteur, aussi bien à l'étranger qu'en France. L'article de Stephen Dumont souligne la place fondamentale de Scot dans l'histoire de la métaphysique. Mais au lieu de se centrer sur la tradition moderne de la métaphysique transcendantale (de Suarez à (...) Kant), il insiste sur le fait que Scot résout l'énigme de la Métaphysique d'Aristote en réduisant sa dimension théologique de celle-ci à sa dimension ontologique. La philosophie scotiste apparaît ainsi comme l'aboutissement d'une exploration systématique des possibilités d'interprétation ouvertes par le texte aristotélicien. L'étude d'Olivier Boulnois fait la transition entre la métaphysique et l'éthique. Elle s'interroge sur le fondement métaphysique de l'éthique scotiste et montre comment le primat d'une volonté libre, et, dans le monde fini, la contingence de la loi morale, s'accompagnent d'une objectivité du bien. La rigueur de la liberté n'est précisément pas l'arbitraire. Gérard Sondag, quant à lui, pose, à partir d'un point très précis d'exégèse aristotélicienne - pour quelle raison le citoyen courageux expose-t-il sa vie quand la Cité est en danger? - la question du fondement éthique du sacrifice de soi. En rejetant, dans sa réponse, toute éthique de l'intérêt personnel, et en posant une objectivité de la norme éthique indépendante de notre propre avantage, Scot ouvre une voie qui conduit à la morale normative de Kant. Duns Scot apparaît ainsi à la fois comme le refondateur de la métaphysique comme discipline transcendantale et comme un penseur original de l'éthique. Unissant ces deux dimensions, il est l'auteur d'une véritable métaphysique de l'éthique. (shrink)

The first edition of Isaac Newton's famous Principia mathematica (1687) contains only one reference to the Scriptures and one mention of God and natural theology. Thus, there is superficial evidence to suggest that this pivotal work of physics is a mostly secular book that is not fundamentally associated with theology and natural theology. The fact that the General Scholium – with its overt theological and natural theological themes – was only added to the Principia a quarter-century later with the second (...) edition of 1713 may also suggest that this theology came as an afterthought and is therefore not integral to the conceptual structure of the Principia . Moreover, the relative paucity of theology in the first edition, combined with the evidence of the appended General Scholium of 1713, could be used as evidence of a ‘theological turn’ in Newton's thought after 1687. This article uses evidence from Newton's private manuscripts to argue that there is more theology in all three editions of the Principia than a simple reading of the published text would imply. This article also demonstrates that the seeds of Newton's theological conception of Nature and the cosmos – conceptions that can be found in manuscripts beginning in the early 1690s, and that are acknowledged in the General Scholium of 1713 – are already present in Newton's private papers prior to 1687. Newton engaged in a great deal of theological writing after 1687, but the period of the composition of the Principia only marks the end of the first third of Newton's six-decade intellectual career and thus it should not be surprising to find more theology after the Principia than before. Nevertheless, there are important theological writings going back to the 1660s that show that Newton's strongly biblical and providentialist theology pre-dates the Principia and, crucially, that his theological conception of the cosmos does as well. The first edition of the Principia , therefore, was composed after Newton had begun to formulate his theology and theological understanding of the cosmos. (shrink)

Pickering & Garrod deserve appreciation for their cogent argument that dialogue merits greater scientific consideration. Current models make little contact with behaviors of dialogue, motivating the interactive alignment theory. However, the theory is not truly “mechanistic.” A full account requires both representations and processes bringing those representations into harmony. We suggest that Grossberg 's adaptive resonance theory may naturally conform to the principles of dialogue.

This book is the compilation of over fifty years of teaching Metaphysics, Philosophy of the Person, Epistemology, and Ethics, including Virtue Ethics, in the classroom setting. Philosophy Begins in Wonder offers the classroom dynamic on the written page. Here you will find philosophical questions raised, many possible answers provided, guidance in discerning how to evaluate the answers, and encouragement for even greater considerations beyond the scope of this book. Philosophy that begins in wonder is open to proceeding further in a (...) lifetime journey of wonder, avoiding the unnecessary pitfalls of cynicism, pessimism, and despair. This spirit of wonder offers to one a life of amazement, joy, gratitude and, therein, often the unexpected moments of knowledge, understanding, insights, and occasionally wisdom. --- back cover of book. (shrink)

A stunning compilation of the strongest pro-choice and pro-life arguments brought together for the first time in a single work that allows for meaningful comparisons and intelligent dialogue. This gives the discerning reader an opportunity to see both sides comprehensively; and move beyond emotionally charged mixed feelings to rational thought.

Within the context of questions raised by gender and sexuality studies about the relationship between sex and technics, I develop a theory of sexuation derived from Gilbert Simondon’s philosophy of individuation. First, I provide an overview of Simondon’s philosophy of individuation, from the physical to the collective. In the second section, I turn to the question of sexuality, outlining an ontogenetic account in which sexuation is conceived as a process of both individuation and relation that is fundamental to certain living (...) beings. Then, drawing on Simondon’s theorization of technics in its mediating function between humans and the world, I resituate understandings of the relation between sex and technics. While each section – Individuation, Sexuation, Technicity – argues for the significance of these concepts to feminist and queer theory, overall the essay uses Simondon’s work as a new paradigm for gender and sexuality studies and calls for the invention of a sexuate culture. (shrink)

This book traces one exegetical, interpretative principal, divine accommodation, in Jewish and Christian thought from the first to the nineteenth century. The focus is upon major figures and the place of accommodation in their work.

The impact of Gilles Deleuze on critical thought in the opening decades of the twenty-first century rivals that of Jacques Derrida or Michel Foucault on critical thought in the closing decades of the twentieth. The "Deleuze and..." industry is in overdrive in the humanities, the social sciences, and beyond, busily connecting Deleuzian philosophy to everything from literature to architecture, metaphysics to mathematics, ethics to physics, sexuality to technology, and ecology to theology. What of Deleuze and the Bible? What does the (...) Bible become when it is plugged into the Deleuzian corpus? An immense affective assemblage, among other things. And what does biblical criticism become in the process? A practice of close reading that is other than interpretation and renounces the concept of representation. The book begins with an extended exposition of Deleuzian thought, and proceeds to unexegetical explorations of five successive themes: Text (how to make yourself a Bible without Organs, and why); Body (why there are no bodies in the Bible, and how to read them anyway); Sex (a thousand tiny sexes, a trillion tiny Jesuses); Race (Jesus and the white faciality machine); and Politics (democracy, despots, pandemics, ancient prophets). Cumulatively, these explorations limn the fluid contours of a Bible after Deleuze. (shrink)

Coercion is commonly said to invalidate consent, and that is always true if the source of the coercion is the physician. However, if it is a family member who coerces the patient to consent, the resultant consent may be quite valid and treatment should proceed.